![]() By combining bioinformatic search to expression profiling, we created a list of 330 genes that contained mononucleotide repeats from 6 to 10 base pairs and were likely to be translated despite potential mutations. Aim of this study was a genome‐wide unbiased identification of new MSI CRC target genes that escape NMD. However, when a premature stop occurs in the carboxyl‐terminal end of the gene it might escape decay mechanisms, which may lead to either dominant‐negative or oncogenic effects. It is generally anticipated that the frameshift mutation‐containing transcripts that lead to prematurely terminated proteins undergo nonsense‐mediated decay (NMD), followed by a reduction in gene expression levels. Genes that mutate this way under MMR deficiency giving selective advantage to cells in tumorigenesis are called MSI target genes. At coding regions instability may lead to frameshift mutations and altered protein products. In cells with a defective MMR system, spontaneous length changes of repetitive microsatellite sequences accumulate all over the genome at highly increased rates. Microsatellite‐instability (MSI) and the underlying mutator phenotype caused by a defect in mismatch repair (MMR) functions is the hallmark of Lynch syndrome, and is also observed in a subset of all colorectal cancers (CRC). My clothes were already on so I decided to leave.Genomic instability drives tumorigenesis by allowing the accumulation of genetic alterations that provide cells with growth advantage. Me and Jack laughed when Hic fully left the room. "We were watching a movie." Jack wrapped his arm around my waist. "What were you guys doing in here?" Hic asked me and Jack once we exited the room. "Love you." I said wrapping my legs around his waist. "Yeah?" Jack lifted his head up from my chest. We both laughed and continued our make out session. "Everything's fine!" Jack answered and we both heard footsteps retreating. "Jack? Is everything okay in there?" Jack's roommate, Hiccup asked. Jack smirked slightly as I felt his hand massaging my breast making me moan. I felt Jack's hand undo my bra (Smuutttyyy), as I took my bra completely off. "I do too." I said with a small peck on his lips. "I love you." Jack whispered into my lips. He got my head and slowly pulled my head to his. Jack looked back at me and my breath turned into a small gasp. I watched as he slowly pulled his jeans down revealing his boxer briefs. I kicked the jeans off the bed and felt Jack unbuckle his belt. I felt his boney hands sneak to the front of my jeans and slid them down. He gently bit my neck, and I think he left a mark. Jack was planting kisses on my collarbone while his hand was exploring my body. I gasped when I felt his 'thing' hit my bottom part. I felt his hand go to the back of my pants and tugged on them. His tongue twirled inside my mouth, making me moan loudly. I parted my lips slightly, and felt his tongue enter the inside of my mouth. Jack gently laid me on his bed, and slowly crawled on top of me while giving me a passionate kiss. Jack did the same with my blouse that he threw across the room. I stopped the kiss for some air, while I slid Jack's shirt off. I felt his hand start to move to my bra which he messed around with. I kiss him back passionately, and I felt his free hand go under my shirt. He lifted my chin up and he kisses me by surprise. ![]() I stared at his blue, snowflake patterned eyes and I smiled. Once we stopped dancing, Jack looked at me, examining every detail on my face. Swirling around his bed, his pile of clothes, and his desk. Once we were in the correct position, we started to twirl around. "Follow my lead." Jack started the dance. ![]() Jack stood up from his chair and walked over to me. "Hi." I waved at him and closed the door behind me. "Hey Els." Jack greeted me once I entered the room. Jack told me to meet in his dorm room so we could practice our waltz. The Winter themed prom which is like, Victory! The teachers wanted us to dance to a waltz.
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